Can generic medications for blood pressure and blood sugar cause your feet and ankles to swell? Yes, according to consultant neurologist Dr Sudhir Kumar, Apollo Hospitals, Hyderabad. “Swelling of the feet and ankles (pedal edema) is a frequent side effect of certain commonly used medicines. The two leading culprits are Amlodipine, a blood pressure medicine, and Pioglitazone, used to control blood sugar in type 2 diabetes,” Dr Kumar noted on Instagram.
He added that amlodipine causes dilation of small arteries, leading to fluid leakage into tissues, while pioglitazone promotes sodium and water retention. “Both can cause soft, pitting ankle swelling, especially in older adults or those on higher doses,” Dr Kumar continued.
Another medicine that can cause similar swelling is Pregabalin, often prescribed for nerve pain. “It increases capillary permeability and venous pooling, sometimes resulting in noticeable foot and ankle puffiness,” said Dr Kumar.
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Here’s what you should consider (Photo: Freepik)
If you notice swelling of your feet after starting any of these medicines, it’s important to inform your doctor. “The dose may need adjustment or an alternative drug may be considered,” said Dr Kumar.
Agreeing, Dr Rajiv Kovil, head of diabetology and weight loss expert, Zandra Healthcare and co-founder, Rang De Neela Initiative, said some commonly prescribed medicines for blood pressure and diabetes, such as Amlodipine and Pioglitazone, can indeed cause mild swelling in the feet or ankles in certain individuals. “Amlodipine, a calcium channel blocker, helps relax blood vessels but may lead to fluid retention in the lower limbs. Similarly, Pioglitazone, used to manage blood sugar in type 2 diabetes, can cause the body to hold extra water, resulting in puffiness or swelling. However, this side effect doesn’t occur in everyone,” he told indianexpress.com.
These medications are effective and safe when taken under proper medical supervision. “Patients should not stop or adjust the dose on their own if they notice swelling. Instead, they should consult their doctor, who may suggest dose modification, switching drugs, or adding a mild diuretic if needed,” said Dr Kovil.
Regular monitoring and timely follow-up can help manage both the condition and the side effects effectively. “Do not just take these medications without the doctor’s knowledge. Exercise caution when it comes to your health and report any problems promptly, in case you are taking these medicines and having any problems,” said Dr Kovil.
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DISCLAIMER: This article is based on information from the public domain and/or the experts we spoke to. Always consult your health practitioner before starting any routine.
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