For many people suffering from chronic migraines, traditional treatments don’t always provide the relief they need. Fortunately, a newer class of drugs called calcitonin gene-related peptide (CGRP) blockers is changing the game.
Medications like Emgality, Aimovig, and Ajovy, all CGRP blockers, have been developed specifically to target the underlying causes of migraines, offering hope for those struggling with frequent attacks.
How Do CGRP Blockers Work?
CGRP is a protein in the body that plays a key role in migraine attacks by widening blood vessels and transmitting pain signals. CGRP blockers work by either preventing CGRP from binding to its receptor or stopping the protein from being released in the first place. This helps reduce the frequency and severity of migraines for many patients.
Comparing Emgality, Aimovig, and Ajovy
While all three medications fall under the CGRP blocker category, they have slight differences:
| Drug Name | Type | How It Works | Dosage & Administration |
|---|
| Emgality | CGRP antibody | Binds directly to CGRP to prevent it from attaching to receptors | Monthly injection |
| Aimovig | CGRP receptor blocker | Blocks the CGRP receptor to stop migraine signals | Monthly injection |
| Ajovy | CGRP antibody | Binds to CGRP to prevent it from triggering migraines | Monthly or quarterly injection |
As the graphic below shows, other anti-CGRP medications have also been approved for use in the U.S. but are different in how and when they are given.
SOURCE: Migrainebuddy.com
Are CGRP Blockers Effective?
Clinical trials and patient experiences show that CGRP blockers can significantly reduce the number of migraine days per month. Some people experience relief within a few weeks, while others may need a few months to see the full benefits. While these medications don’t work for everyone, they offer a promising alternative for those who haven’t responded well to traditional migraine treatments.
What to Consider Before Trying CGRP Blockers
- Side Effects: Common side effects include injection site reactions, constipation (especially with Aimovig), and mild allergic reactions.
- Insurance Coverage: Some insurance plans may require prior authorization, so it’s important to check coverage options.
- Suitability: These drugs are typically recommended for those with frequent or chronic migraines who haven’t found relief with other treatments.
Interested in Learning More?
If you’re struggling with migraines and want to explore whether preventive CRGP blockers like Emgality, Aimovig, or Ajovy could be right for you, the Migraine Relief Center is here to help. Our specialists can assess your condition and guide you toward the best treatment plan for your needs.
Schedule an appointment today to take the next step toward lasting migraine relief!
