Early Intervention Curbs Peanut Allergies in Babies – Research

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In a study involving 22 infants enrolled in an early peanut oral immunotherapy program to curb peanut allergies at Cleveland Clinic’s Food Allergy Center of Excellence in the U.S., researchers found that starting peanut oral immunotherapy under medical supervision during infancy can improve a child’s immune response to the food over time. The findings were recently published in the Journal of Allergy & Clinical Immunology: In Practice.

Cleveland Clinic is one of a few health systems in the U.S. to offer oral immunotherapy for babies and toddlers who are allergic to peanuts. Through its Food Allergy Center of Excellence, children under age four have developed a tolerance for the food by eating tiny amounts of them in a step-by-step, controlled process.

According to Sandra Hong, M.D., allergist and director of the Food Allergy Center of Excellence at Cleveland Clinic peanut oral immunotherapy is well-tolerated in toddlers, but there is limited real-world evidence available to demonstrate the benefits in babies. Data was leveraged from infants in their program to understand the safety and efficacy of this treatment in children 12 months and younger.

Study to curb peanut allergies in babies

For the retrospective study, the research team reviewed data from 22 infants – ages 7 to 11 months – who received peanut oral immunotherapy. Through an allergist and parent-implemented plan, children were started on a daily dose of 18 milligrams (about twice the weight of a grain of table salt) of peanut protein in the form of peanut butter or peanut powder.

Over six months, they were slowly given larger servings to consume every day until they reached a maintenance dose of 500 milligrams (the equivalence of two peanut kernels).

Researchers found that all 22 babies in the cohort achieved this milestone. During treatment, more than half experienced mild allergic reactions which resolved on their own, and one required epinephrine. Around 27% of the babies had experienced no allergic reactions whatsoever.

Safety was paramount. Each time babies were exposed to a larger amount of peanut protein, it was done under the careful supervision of an allergist. They were monitored for an hour after the higher dose was given.

Upon completing peanut oral immunotherapy, 14 of the 22 babies received an allergy test to check their levels of peanut-specific antibodies. The results indicated that all 14 babies had a reduced sensitivity to peanuts.

Then, 11 of those babies participated in an oral food challenge where they were fed increasing doses of peanut protein up to 2,000 milligrams (about nine peanuts). After completing the challenge, 91% of them could tolerate peanuts without triggering any allergic reactions.

“The study shows that the majority of babies were able to safely consume peanuts after oral immunotherapy,” said Sarah Johnson, M.D., lead author of the study and a fellow at Cleveland Clinic. “Overall, this signals that age is a crucial factor in the success of this treatment. An infant’s immune system is more adaptable, allowing them to develop tolerance to peanuts with less severe reactions and fewer side effects than older children.”

While peanut oral immunotherapy holds promise in helping young children overcome peanut allergies, the treatment should always be done under the care of a trained allergist.

“At the end of the day, we want families to be safe,” said Dr. Hong. “This is not something you try on your own because of the significant risk of triggering allergic reactions. When you have an allergist supervise the process, you are ensuring that any reactions your child experiences are quickly identified and treated.”

Peanut allergy is a condition that causes the body’s germ-fighting immune system to react to peanuts. It’s one of the most common causes of a life-threatening allergic reaction to food. This life-threatening reaction is known as anaphylaxis.

Peanut allergy has been increasing in children. Even if you or your child has shown only a mild reaction to peanuts, talking to a healthcare professional is important. There is still a risk of a more serious future reaction.

Suggested reading: Health Library

Early Intervention Curbs Peanut Allergies in Babies – Research was last modified: December 6th, 2024 by Vidya Sury

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