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      Types, Symptoms, Causes, and More

      Sarah Bradley by Sarah Bradley
      24/03/2025
      in Uncategorized
      Types, Symptoms, Causes, and More

      The endocrine system is made of glands that produce hormones (chemical messengers), which all have different jobs in the body.

      An endocrine disorder occurs when your endocrine system produces too much or too little of a hormone or when the body doesn’t respond to hormones correctly.

      In the United States, about 5% of adults have an endocrine disorder. Diabetes is the most common. Endocrine disorders often have different symptoms, treatments, and long-term outlooks depending on what part of the endocrine system is affected.

      There are many types of endocrine disorders, including:

      • Metabolic disorders: These relate to how your body makes or responds to insulin, a hormone your pancreas makes that helps your cells use glucose for energy. Examples include type 1 diabetes, type 2 diabetes, and gestational diabetes.
      • Thyroid disorders: Thyroid hormones influence how your body uses energy, which can affect your heart rate, breathing, and digestion. Examples of thyroid disorders include hyperthyroidism and hypothyroidism. 
      • Adrenal disorders: Your adrenal glands are on each kidney. They make stress hormones and some sex hormones. Examples of adrenal disorders include Addison’s disease and Cushing’s syndrome.
      • Pituitary disorders: The pituitary gland in your brain helps control your growth and influences the activity of other glands. Examples of pituitary disorders include dwarfism and acromegaly (gigantism).
      • Sex hormone disorders: The ovaries and testes are part of the endocrine system. They make hormones that help your reproductive system develop. Examples of sex hormone disorders include early puberty and polycystic ovary syndrome (PCOS).
      • Parathyroid disorders: The parathyroid glands make hormones that help balance calcium and phosphorus, two key minerals in your blood. Examples of these disorders include hyperparathyroidism and hypoparathyroidism.

      Because hormones tell your body how to work, a hormone imbalance can seriously affect your health. Many endocrine disorders cause fatigue and mood changes, but symptoms can vary widely based on the disorder. Some of these symptoms include: 

      Endocrine disorder type Symptoms
      Metabolic disorderFatigue, high or low blood sugar, weight gain or loss, excessive hunger or thirst 
      Thyroid disorderFatigue, weight gain or loss, muscle weakness, dry skin, feeling cold, rapid or slow heart rate, mood changes, sleeping trouble, diarrhea or constipation 
      Adrenal disorderFatigue; mood changes; high or low blood pressure; skin health changes; menstrual period changes; stomach problems like constipation, diarrhea, nausea, and vomiting
      Pituitary disorderFatigue, weakness, weight changes, low blood pressure, sexual issues, rapid body growth, joint pain, increased body hair
      Sex hormone disorderDelayed or early puberty, slow or rapid body growth, swollen breast tissue, fertility issues
      Parathyroid disorderFatigue, bone pain, kidney stones, a strong urge to pee, tingling in your arms and legs, muscle cramps, dry skin and nails, seizures, tooth problems

      Endocrine disorders occur when an endocrine gland makes too many or too few hormones. It can also happen when your body can’t respond to the hormones well enough. For example, some people with type 2 diabetes make enough insulin, but their bodies don’t use it the right way.

      Tumors, autoimmune disorders, and infections can also lead to endocrine disorders.

      Risk Factors

      Some people have a higher risk of endocrine disorders based on factors such as:

      • Family history: You may be more likely to have a condition if you have a relative with that disorder.
      • Genetics: Some endocrine disorders may be inherited (passed down through families).
      • Age: Different endocrine disorders are more common in older or younger people. Type 1 diabetes, for example, is more common in children and young adults, but type 2 diabetes is more common after age 45. 
      • Sex: Some endocrine diseases are linked to your biological sex, including sex hormone disorders, thyroid disease, and hyperparathyroidism.
      • Environmental exposure to chemicals: Some experts believe repeated exposure to certain chemicals can affect your body’s hormones over time. 
      • Other health conditions: People with chronic health conditions like obesity or hypertension (high blood pressure) are more likely to develop certain endocrine disorders, such as thyroid disease or diabetes.

      Healthcare providers diagnose each endocrine disorder differently, as different tests show signs of different disorders. In addition to your medical history and a physical exam, tests healthcare providers may use to diagnose an endocrine disorder include:

      Many treatments are available for endocrine disorders. Some disorders may be cured with surgery, while others require ongoing treatment with medication or lifestyle changes. Each treatment option aims to help the body function as close to normal as possible. 

      Medications

      Prescription medication can help many people manage their endocrine disorders. Medications differ depending on the condition.

      Some examples include insulin injections and metformin, which help maintain blood sugar levels. Your healthcare provider may also recommend hormone medications, which can help increase or decrease the production of different hormones.

      Surgery

      A surgeon can remove glands that don’t work correctly or have tumors. Surgery is commonly used for certain endocrine disorders, such as problems with the adrenal, pituitary, parathyroid, and thyroid glands.

      Lifestyle Changes

      Lifestyle approaches may help improve symptoms for many endocrine disorders. These approaches include exercising regularly, eating a balanced and nutritious diet, and not smoking or drinking alcohol. That said, you may still need to take medication or undergo surgery to keep your disorder from affecting your health.

      Some health conditions are more likely if you have an endocrine disorder, including:

      • High blood pressure: Some endocrine disorders may trigger high blood pressure.
      • Fertility problems: Some endocrine disorders can negatively affect ovulation, menstruation, and sperm quality or production. This can make pregnancy more challenging.
      • Neurological conditions: The endocrine system is related to your nervous system, which controls many of your body’s daily tasks. People with endocrine disorders are more likely to have headaches, vision changes, and muscle pain or weakness. 

      Endocrine disorders can be dangerous or life-threatening for some people, especially if left untreated. Untreated endocrine disorders may also increase your risk of infections, poor heart health, depression, and certain cancers.

      Most endocrine disorders are treatable, with many people experiencing few symptoms or complications. It’s essential to get treatment and work with a healthcare provider to help manage your disorder.



      Thanks for your feedback!

      Health.com uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
      1. United States Environmental Protection Agency. Overview of the endocrine system.

      2. MedlinePlus. Endocrine disorders.

      3. Golden SH, Robinson KA, Saldanha I, Anton B, Ladenson PW. Prevalence and incidence of endocrine and metabolic disorders in the United States: A comprehensive review. J Clin Endocrinol Metab. 2009;94(6):1853. doi:10.1210/jc.2008-2291

      4. MedlinePlus. Diabetes.

      5. National Institute of Diabetes and Digestive and Kidney Diseases. Hyperthyroidism.

      6. MedlinePlus. Hypothyroidism.

      7. MedlinePlus. Adrenal gland disorders.

      8. MedlinePlus. Pituitary disorders.

      9. Open Resources for Nursing. Chapter 17 endocrine system terminology. In: Ernstmeyer K, Christman E, eds. Medical Terminology. 2nd ed. Chippewa Valley Technical College; 2024.

      10. Endocrine Society. Polycystic ovary syndrome.

      11. Breehl L, Caban O. Physiology, puberty. In: StatPearls. StatPearls Publishing; 2025.

      12. MedlinePlus. Parathyroid disorders.

      13. MedlinePlus. Hyperparathyroidism.

      14. MedlinePlus. Hypoparathyroidism.

      15. Office on Women’s Health. Thyroid disease.

      16. Eunice Kennedy Shriver National Institute of Child Health and Human Development. What are the symptoms of adrenal gland disorders?.

      17. American Cancer Society. Signs and symptoms of pituitary tumors.

      18. Merck Manual: Professional Version. Overview of endocrine disorders.

      19. Centers for Disease Control and Prevention. Diabetes risk factors.

      20. American Cancer Society. Risk factors for pituitary tumors.

      21. Alyahya A, AlNaim A, AlBahr AW, Almansour F, Elshebiny A. Knowledge of thyroid disease manifestations and risk factors among residents of the eastern province, Saudi Arabia. Cureus. 2021;13(1):e13035. doi:10.7759/cureus.13035

      22. National Institute of Diabetes and Digestive and Kidney Diseases. Primary hyperparathyroidism.

      23. National Institute of Environmental Health Sciences. Endocrine disruptors.

      24. Liu F, Zhang X. Hypertension and obesity: Risk factors for thyroid disease. Front Endocrinol. 2022;13:939367. doi:10.3389/fendo.2022.939367

      25. MedlinePlus. Growth hormone tests.

      26. Centers for Disease Control and Prevention. Diabetes testing.

      27. Eunice Kennedy Shriver National Institute of Child Health and Human Development. How do healthcare providers diagnose Turner syndrome?.

      28. MedlinePlus. Urinalysis.

      29. American Cancer Society. Tests for pituitary tumors.

      30. National Institute of Diabetes and Digestive and Kidney Diseases. Insulin, medicines, and other diabetes treatments.

      31. American Cancer Society. Medications to treat pituitary tumors.

      32. Cleveland Clinic. Adrenalectomy (adrenal gland removal).

      33. American Thyroid Association. Thyroid surgery.

      34. Kalra S, Kumar A, Aswathy S, Shriraam V. Community endocrinology. Indian J Endocrinol Metab. 2015;19(6):695. doi:10.4103/2230-8210.167564

      35. Endocrine Society. Endocrine related hypertension.

      36. Endocrine Society. Reproductive infertility.

      37. Yu J. Endocrine disorders and the neurologic manifestations. Ann Pediatr Endocrinol Metab. 2014;19(4):184. doi:10.6065/apem.2014.19.4.184

      38. MedlinePlus. Diabetes complications.

      39. Salvador J, Gutierrez G, Llavero M, Gargallo J, Escalada J, López J. Endocrine disorders and psychiatric manifestations. In: Portincasa P, Frühbeck G, Nathoe HM, eds. Endocrinology and Systemic Diseases. Springer International Publishing; 2020:1-35. doi:10.1007/978-3-319-66362-3_12-1

      40. Vemula SL, Aramadaka S, Mannam R, et al. The impact of hypothyroidism on diabetes mellitus and its complications: A comprehensive review. Cureus. 2023;15(6):e40447. doi:10.7759/cureus.40447

      41. MedlinePlus. Multiple endocrine neoplasia.

      42. Hallberg SJ, Gershuni VM, Hazbun TL, Athinarayanan SJ. Reversing type 2 diabetes: A narrative review of the evidence. Nutrients. 2019;11(4):766. doi:10.3390/nu11040766

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